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1000Mg Evening Primrose Oil


What is it?


Evening primrose oil (EPO) is made from the seeds of the flowers of a plant native to North America. The plant has traditionally been used to treat:

  • bruises
  • hemorrhoids
  • digestive problems
  • sore throats

Its healing benefits may be due to its gamma-linolenic acid (GLA) content. GLA is an omega-6 fatty acid found in plant oils.

EPO is generally taken as a supplement or applied topically. Read on to learn how EPO may help treat many common health conditions today.

Ready to give it a try? Find EPO here.


1. It can help clear up acne


The GLA in EPO is thought to help acne by reducing skin inflammation and the number of skin cells that cause lesions. It may also help the skin retain moisture.


According to a 2014 studyTrusted Source, EPO may help relieve cheilitis. This condition causes inflammation and pain in the lips caused by the acne drug isotretinoin (Accutane).

A separate study found that GLA supplementation reduced both inflammatory and noninflammatory acne lesions.


2. It may help ease eczema


Some countries other than the United States have approved EPO to treat eczema, an inflammatory skin condition.

According to an older study, the GLA in EPO may improve the skin’s epidermis. 


3. It can help improve overall skin health


According to a 2005 study, oral supplementation of EPO helps smooth skin and improve its:

  • elasticity
  • moisture
  • firmness
  • fatigue resistance


Per the study, GLA is necessary for ideal skin structure and function. Because the skin can’t produce GLA on its own, researchers believe taking GLA-rich EPO helps keep skin healthy overall.


4. It may help relieve PMS symptoms


An older studyTrusted Source suggests EPO is highly effective in treating premenstrual syndrome (PMS) symptoms, such as:

  • depression
  • irritability
  • bloating


Researchers believe some women experience PMS because they’re sensitive to normal prolactin levels in the body. GLA converts to a substance in the body (prostaglandin E1) thought to help prevent prolactin from triggering PMS.


According to a 2010 studyTrusted Source, a supplement containing vitamin B-6, vitamin E, and EPO was effective in relieving PMS. Even so, it’s unclear how much EPO played a role, since a 2009 systematic reviewTrusted Source didn’t find EPO helpful for PMS.


5. It can help minimize breast pain


If you experience breast pain so severe during your period that it interferes with your life, taking EPO may help.


According to a 2010 study, the GLA in EPO is thought to reduce inflammation and help inhibit prostaglandins that cause cyclical breast pain. The study found that taking daily doses of EPO or EPO and vitamin E for six months decreased the severity of cyclical breast pain.


6. It may help reduce hot flashes


EPO may reduce the severity of hot flashes, one of the most uncomfortable side effects of menopause.

According to a 2010 literature review, there’s not enough evidence that over-the-counter remedies such as EPO help hot flashes.


A later study, however, came to a different conclusion. The study found that women who took 500 mg daily of EPO for six weeks experienced less frequent, less severe, and shorter hot flashes.


Women also had improved marks for social activity, relations with others, and sexuality on a questionnaire on how hot flashes impact daily life.


7. It may help reduce high blood pressure


According to a 2013 studyTrusted Source, those taking EPO had a slightly higher systolic blood pressure. Researchers called the reduction “a clinically meaningful difference.”

A 2011 systemic reviewTrusted Source concluded there’s not enough evidence to determine if EPO helps reduce the risk of high blood pressure during pregnancy or preeclampsia, a condition that causes dangerously high blood pressure during and after pregnancy.


8. It may help improve heart health


Heart disease kills more than 600,000 peopleTrusted Source in the United States each year. Hundreds of thousands more are living with the condition. Some people are turning to natural remedies, such as EPO, to help.


According to a 2014 studyTrusted Source on rats, EPO is anti-inflammatory and helps reduce blood cholesterol. Most people with heart disease have inflammation in the body, although it hasn’t been proven that inflammation causes heart disease.


9. It can help reduce nerve pain

Peripheral neuropathy is a common side effect of diabetes and other conditions. Older research has shown that taking linolenic acid helps reduce neuropathy symptoms, such as:

  • hot and cold sensitivity
  • numbness
  • tingling
  • weakness


How to use: Take one N22 EPO capsule daily.


10. It may help ease bone pain


Bone pain is often caused by rheumatoid arthritis, a chronic inflammatory disorder. According to a 2011 systematic review, the GLA in EPO has the potential to reduce rheumatoid arthritis pain without causing unwanted side effects.


If you take blood thinners, EPO may increase bleeding. EPO may lower blood pressure, so don’t take it if you take medications that lower blood pressure or blood thinners.


There’s evidence that EPO may benefit some conditions on its own or as a complementary therapy, but more research is needed. Until the verdict is clear, EPO shouldn’t be used in place of a treatment plan recommended by your doctor.


There’s no standardized dosing for EPO. Most dosage recommendations are based on what’s been used in research.

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